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Biologists and radiotherapists current their experimental paintings and medical facts within the box of radiation accidents of standard tissues and organs. specific regard is payed to the relevance of organic mechanisms in scientific occasions. ideas of radiation harm and mixed remedy toxicity in radio-chemotherapy are being defined. the most themes mentioned are the significance of microvasculature, time, doseand fractionation and components enhancing scientific radioresponse for early andlate radiation results. Tissues and organs thought of during this quantity are mucosa and pores and skin, lung and middle, bladder and muscle, CNS and eye. targeted difficulties of pediatric radiotherapy, TBI, IORT and moment malignacies also are mentioned.
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Extra resources for Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance
However, clonogenic tumor cells may re populate the tumor during such treatment gaps, thereby increasing the dose necessary to achieve local tumor control. This was demonstrated by Overgaard et al. 0 Gy per week) or "split-course" radiotherapy, that is an interruption of the treatment for 3 weeks after the first 20 fractions had been applied. Table 3 shows that the dose necessary to obtain 65% local tumor control increased Table 2. Effect of smoking during radiation therapy (RT) on acute mucositis (Rugg et al.
As the X-ray dose increases, RBE increases, which reflects increasing X-ray resistance. 5 Gy after which it decreases with increasing dose, which is the conventional picture due to the downward bending of the X-ray survival curve. C. Joiner et al. 6 2 4 6 10 (Gy) Fig. 6. , Fig. 5) where each estimate of cell survival after a single X-ray dose is expressed as an RBE value relative to the line fitted to survival after neutrons, measured in the same experiment (see text). 2Gy. 1 to 1 Gy. , with the LQ model) from high-dose data.
Mutat Res 173:291-293 Koval TM (1988) Enhanced recovery from ionizing radiation damage in a lepidopteran insect cell line. Radiat Res 115:413-420 Marples B, Joiner MC (1992) The response of V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population. C. : The Response of Tissues to Very Low Doses per Fraction Palcic B, Jaggi B (1986) The use of solid state sensor technology to detect and characterise live mammalian cells growing in tissue culture. Int J Radiat Bioi 50:345-352 Papathanasiou MA, Kerr NCK, Robbins JH, McBride OW, Alamo I, Barrett SF, Hickson ID, Fornace AJ (1991) Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.
Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance by J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)