By François-Xavier Theillet, Pierre Chassagne (auth.), Paul Kosma, Sven Müller-Loennies (eds.)
Many pathogens and aberrant malignant cells show detailed carbohydrates on their floor representing beautiful ambitions for vaccine layout. substantial development has lately been made within the id of novel carbohydrate established vaccines and a multitude has reached medical part reports. The good fortune of numerous approved carbohydrate established vaccines opposed to bacterial pathogens similar to Haemophilus influenzae kind b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their nice capability. even though, the examine of anti-carbohydrate antibodies is technically tough and partially due to low affinities and promiscuous specificity they've got no longer been medically exploited to complete power. The examine of antibody specificities and id of protecting carbohydrate epitopes lies on the center of winning vaccine layout. as well as remedy, antibodies typically function diagnostic instruments in clinical and medical laboratories. during this environment excessive affinity and beautiful specificity are very important elements for his or her winning use. “Anticarbohydrate Antibodies – from molecular foundation to medical program” compiles present wisdom at the immunological popularity of carbohydrates through the adaptive immune procedure from a molecular point of view supplying basic perception wanted for advancing clinically appropriate diagnostics and healing functions. in response to major development within the fields of glycoimmunology and structural biology lately, the ebook comprehensively studies the state of the art in defining the main parts of carbohydrate attractiveness via antibodies, the molecular mimicry of carbohydrate epitopes in addition to the molecular positive factors resulting in particular and secure binding modes. Backed-up via a mixture of contemporary applied sciences to explain structural information of carbohydrate-antibody interactions, biomedically very important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells were analyzed in in-depth stories written through famous specialists within the box. basic wisdom of those molecular mechanisms finally presents a rational foundation to enhance efficacy of carbohydrate-based vaccines and to extra refine diagnostic instruments in detection of pathogens and malignant cells.
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Additional resources for Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application
Science 305:522–525 Villeneuve S, Boutonnier A, Mulard LA, Fournier JM (1999) Immunochemical characterization of an Ogawa-Inaba common antigenic determinant of Vibrio cholerae O1. Microbiology 145:2477–2484 Villeneuve S, Souchon H, Riottot MM, Mazie JC, Lei P, Glaudemans CPJ, Kovac P, Fournier JM, Alzari PM (2000) Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity. Proc Natl Acad Sci USA 97:8433–8438 Vulliez-Le Normand B, Saul FA, Phalipon A, Belot F, Guerreiro C, Mulard LA, Bentley GA (2008) Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody.
In contrast, addition of rhamnose B2 improved the binding free energy DG by À2 kcalÁmolÀ1, on average. The key role of residue B2 in Ab recognition was more general, since B2(E2)C2D2 was also recognized by IgG D15-7 and IgG E4-1. However, the minimal sequences necessary for recognition by IgG A2-1 and IgG C1-7 was the B2(E2)C2D2 0 tetrasaccharide flanked by residue A2/A2 at either end (Phalipon et al. 2006). 1), thus constricting Ab classification into two major families. Overall, the B2(E2)C2D2 fragment was seen as an immunodominant “protective” determinant, where OS elongation correlated with an increase in mAb binding.
Conformational analysis of a heptasaccharide hapten utilizing a combined molecular dynamics and NMR spectroscopic protocol. Theochem J Mol Struct 395:389–409 Kubler-Kielb J, Vinogradov E, Chu C, Schneerson R (2007) O-Acetylation in the O-specific polysaccharide isolated from Shigella flexneri serotype 2a. Carbohydr Res 342:643–647 Kubler-Kielb J, Vinogradov E, Mocca C, Pozsgay V, Coxon B, Robbins JB, Schneerson R (2010) Immunochemical studies of Shigella flexneri 2a and 6, and Shigella dysenteriae type 1 O-specific polysaccharide-core fragments and their protein conjugates as vaccine candidates.
Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application by François-Xavier Theillet, Pierre Chassagne (auth.), Paul Kosma, Sven Müller-Loennies (eds.)