By Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD (eds.)
The volumes incorporated in Antimicrobial Drug Resistance symbolize the 1st complete, multidisciplinary reference masking the realm of antimicrobial drug resistance in micro organism, fungi, viruses, and parasites from uncomplicated technological know-how, scientific, and epidemiological perspectives.
The first quantity, Antimicrobial Drug Resistance, Mechanisms of Drug Resistance, is devoted to the organic foundation of drug resistance and potent avenues for drug improvement. With the emergence of extra drug-resistant traces, the method of facing the drug resistance challenge needs to contain the examine of other facets of the mechanisms of bacterial resistance and the dissemination of resistance genes in addition to study using new genomic details. those ways will let the layout of novel ideas to strengthen new antibiotics and defend the effectiveness of presently to be had ones.
The moment quantity, Antimicrobial Drug Resistance, medical and Epidemiological Aspects, is dedicated to the medical features of drug resistance. even supposing there's facts that constrained use of a selected antibiotic may be by way of a reduce in drug resistance to that agent, drug resistance keep watch over isn't really simply completed. hence, the infectious sickness health practitioner calls for enter from the medical microbiologist and an infection regulate professional to make educated offerings for the potent therapy of varied lines of drug-resistant pathogens in person patients.
This 2-volume set is a crucial reference for college students in microbiology, infectious disorder physicians, clinical scholars, easy scientists, drug improvement researchers, microbiologists, epidemiologists, and public health and wellbeing practitioners.
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Additional info for Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects
The problem with imipenem is that there are no NCCLS breakpoints for non-pneumococcal streptococci (44). Streptococci are in vitro highly susceptible to another carbapenem compound, meropenem. Only few resistant strains with MICs as high as 2 mg/L have been found (46). 2 Resistance to Macrolides, Lincosamides and Ketolides Macrolides, ketolides, lincosamides and streptogramin B antibiotics, although having different kind of chemical structure, all have similar although not identical antimicrobial activity against VGS.
Earlier, so-called nutritionally variant streptococci were included in the VGS but based on the molecular data they have now been removed to a new genus Abiotrophia (3) and are not included in the discussion below. VGS belong to the normal microbiota of the oral cavities and upper respiratory tracts of humans and animals. They can also be isolated from the female genital tract and all regions of the gastrointestinal tract (2, 3). Several species are included in VGS and are listed elsewhere (2, 3).
Talbot TR, Poehling KA, Hartert TV, et al. Reduction in high rates of antiobiotic-nonsusceptible invasive pneumococcal disease in Tennessee following introduction of the pneumococcal conjugate vaccine. Clin Infect Dis 2004;39:641–648 179. Stephens DS. Incidence of macrolide resistance in Streptococcus pneumoniae after introduction of the pneumococcal conjugate vaccine: population-based assessment. Lancet 2005;365:855–863 180. Kyaw MH, Lynfield R, Schaffner W, et al. Effect of introduction of the pneumococcal conjugate vaccine on drugresistant Streptococcus pneumoniae.
Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects by Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD (eds.)